| Autor: |
Carlos G. Sanchez, Christopher M. Acker, Audrey Gray, Malini Varadarajan, Cheng Song, Nadire R. Cochran, Steven Paula, Alicia Lindeman, Shaojian An, Gregory McAllister, John Alford, John Reece-Hoyes, Carsten Russ, Lucas Craig, Ketthsy Capre, Christian Doherty, Gregory R. Hoffman, Sarah J. Luchansky, Manuela Polydoro, Ricardo Dolmetsch, Fiona Elwood |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2399-3642 |
| DOI: |
10.1038/s42003-021-02272-1 |
| Popis: |
Using an unbiased genome-wide CRISPR screen approach, Sanchez et al. identified modulators of endogenous tau protein. This study suggests that chromatin modifiers, neddylation, ubiquitination, and the mTOR pathways regulate overall levels of tau protein in neurons, which could help in future identification of therapeutics for neurodegenerative diseases. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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