Nrf2-mediated redox balance alleviates LPS-induced vascular endothelial cell inflammation by inhibiting endothelial cell ferroptosis

Autor:	Huimin Hou, Xiujiao Qin, Gaokai Li, Zhitao Cui, Jin Zhang, Bin Dong, Zhicheng Wang, Huiying Zhao
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-53976-3
Popis:	Abstract Ferroptosis plays an important role in inflammation and oxidative stress. Whether ferroptosis is involved in the inflammation of vascular endothelial cells and its regulation mechanism remains unclear. We estimated the correlation between serum iron ion levels and the inflammation index of 33 patients with arteriosclerosis. In vitro, HUVECs with or without ferrostatin-1 were exposed to Lipopolysaccharide. Corresponding cell models to verify the target signaling pathway. The results showed that serum iron ion levels had a significant positive correlation with N ratio, N/L, LDL level, and LDL/HDL (P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/6971b4c264434c5b95c6ca6ee0e939e5 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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