Beneficial body mass index to enhance survival outcomes in patients with early-stage hepatocellular carcinoma following microwave ablation treatment
| Autor: | Jian-Ping Dou, Zhi-Yu Han, Fangyi Liu, Zhigang Cheng, Xiaoling Yu, Jie Yu, Ping Liang |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | International Journal of Hyperthermia, Vol 37, Iss 1, Pp 110-118 (2020) |
| Druh dokumentu: | article |
| ISSN: | 0265-6736 1464-5157 02656736 |
| DOI: | 10.1080/02656736.2020.1712482 |
| Popis: | Purpose To identify the beneficial body mass index (BMI) for patients with hepatocellular carcinoma (HCC) to achieve longer survival time following curative microwave ablation (MWA). Methods This retrospective study evaluated 474 patients with solitary primary HCC who underwent MWA. BMI at initial admission and other characteristics were collected. The associations of the BMI with the overall survival (OS) and disease-free survival (DFS) were analyzed by Cox proportional hazards regression analysis in multiple models. A two-piecewise linear regression model was applied to examine the threshold effect of the BMI on OS and DFS by maximized log likelihood method. The threshold level was determined by using trial and error. Results Patients with a normal BMI range achieved improved survival outcomes but similar DFS in multiple models. In the model with adjustments of the age, size, and Charlson score, patients with BMI ≤ 22.9 and ≤24.9 kg/m2 exhibited a lower death rate than patients with BMI ≤18.5 kg/m2 (p |
| Databáze: | Directory of Open Access Journals |
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