Correlation of biochemical profile at admission with severity and outcome of COVID-19

Autor: Abdullah Sadiq, Muhammad Khurram, Javaria Malik, Noman Ahmed Chaudhary, Muhammad Mujeeb Khan, Tahira Yasmeen, Hamza Waqar Bhatti
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 6, Pp 740-746 (2021)
Druh dokumentu: article
ISSN: 2000-9666
20009666
DOI: 10.1080/20009666.2021.1974161
Popis: Background COVID-19 was detected in China in December 2019. The rapid dissemination and novelty of the disease resulted in an epidemic. This study aimed to identify biochemical parameters at admission that can be used to categorize severity and outcome of COVID −19 infection. Materials and Methods This cross-sectional study was conducted at Allied Hospitals of RMU from April 2020 to July 2020. It included 128 randomly selected confirmed COVID-19 patients. At admission, biochemical profile (total bilirubin, alanine aminotransferases {ALT}, aspartate aminotransferases {AST}, urea, creatinine, uric acid, sodium, potassium, and chloride were correlated with severity and outcome of COVID-19 by employing t-tests and ANOVA where required. Cut-off values to predict disease severity and outcome were calculated using ROC curve. Results The study comprised 46.1% non-severe, 29.7% severe, and 24.2% critical COVID-19 patients. 84.4% patients improved and 15.6% expired. Urea was increased in critical disease patients (p 42.7 mg (sensitivity of 64.7%, specificity of 87.5%), AST >43.5 IU/L (64% sensitivity, 60% specificity), and sodium
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje