KAT2-mediated PLK4 acetylation contributes to genomic stability by preserving centrosome number

Autor:	Marjorie Fournier, László Tora
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	acetylation cell cycle centrosome gcn5 genome stability inhibition kinase activity pcaf polo like kinase 4 (plk4) proteomic analysis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Molecular & Cellular Oncology, Vol 4, Iss 2 (2017)
Druh dokumentu:	article
ISSN:	2372-3556 23723556
DOI:	10.1080/23723556.2016.1270391
Popis:	We have recently identified the first human lysine (K) acetyltransferase 2A and 2B (called KAT2A/2B; known also as GCN5/PCAF, respectively)-dependent acetylome and revealed a mechanism by which KAT2A/2B-mediated acetylation of serine/threonine polo-like kinase 4 (PLK4) maintains correct centrosome number in human cells, therefore contributing to the maintenance of genome stability.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/ec6964e0158c4803b495f44a677e95b3 Zobrazit plný text záznamu View record in DOAJ