Atrial Fibrillation and Beta Thalassemia Major: The Predictive Role of the 12-lead Electrocardiogram Analysis

Autor: Vincenzo Russo, MD, PhD, MMsc, Anna Rago, MD, Bruno Pannone, (MD), Maria Carolina Mayer, MD, Anna Spasiano, MD, Raffaele Calabro, MD, PhD, Maria Giovanna Russo, MD, Nigro Gerardo, MD, PhD
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Indian Pacing and Electrophysiology Journal, Vol 14, Iss 3, Pp 121-132 (2014)
Druh dokumentu: article
ISSN: 0972-6292
DOI: 10.1016/S0972-6292(16)30753-7
Popis: Background: Paroxysmal atrial tachyarrhythmias frequently occur in beta-thalassemia major (β-TM) patients.The aim of our study was to investigate the role of maximum P-wave duration (P max) and dispersion (PD), calculated trough a new manually performed measurement with the use of computer software from all 12-ECG-leads, as predictors of atrial-fibrillation (AF)in β-TM patients with conserved systolic or diastolic cardiac function during a twelve-months follow-up. Materials and Methods: 50 β-TM-patients (age38.4±10.1; 38M) and 50-healthy subjects used as controls, matched for age and gender, were studied for the occurrence of atrial arrhythmias during a 1-year follow-up, through ECG-Holter-monitoring performed every three months. The β-TM-patients were divided into two groups according to number and complexity of premature-supraventricular-complexes at the Holter-Monitoring (Group1: 30/h or couplets, or run of supraventricular tachycardia and AF, n:15). Results: Compared to the healthy control-group, β-TM patients presented increased P-max (107.5± 21.2 vs 92.1±11ms, P=0.03) and PD-values (41.2±13 vs 25.1±5 ms, P=0.03). In the β-TM population, the Group2 showed a statistically significant increase in PD (42.8±8.6 vs 33.2±6.5ms, P
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