| Autor: |
Da Pan, Ligang Yang, Xian Yang, Dengfeng Xu, Shaokang Wang, Han Gao, Hechun Liu, Hui Xia, Chao Yang, Yifei Lu, Jihan Sun, Yuanyuan Wang, Guiju Sun |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Journal of Advanced Research, Vol 57, Iss , Pp 77-91 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2090-1232 |
| DOI: |
10.1016/j.jare.2023.04.005 |
| Popis: |
Introduction: Nutritional support is potentially considered an essential step to prevent muscle loss and enhance physical function in older adults. Objectives: This study aimed to assess the role of potential nutritional strategies, i.e., fish oil-derived ω-3 polyunsaturated fatty acids (PUFAs), wheat oligopeptide and their combined intervention, in preventing and reversing sarcopenia in aging process. Methods: One hundred 25-month-old Sprague-Dawley rats were randomly divided into 10 groups, and 10 newly purchased 6-month-old rats were included in young control group (n = 10). Fish oil (200, 400 or 800 mg/kg body weight), wheat oligopeptide (100, 200 or 400 mg/kg body weight), fish oil + wheat oligopeptide (800 + 100, 400 + 200 or 200 + 400 mg/kg body weight) or the equal volume of solvent were administered daily by gavage for 10 weeks. The effects of these interventions on natural aging rats were evaluated. Results: All intervention groups had a significant increase in muscle mass and grip strength and reduction in perirenal fat weight when compared to the aged control group (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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