Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate

Autor: J. L. Imbach, J. L. Barascut, H. B. Lazrek, M. Taourirte, A. Rochdi
Jazyk: angličtina
Rok vydání: 2000
Předmět:
Zdroj: Molecules, Vol 5, Iss 10, Pp 1139-1145 (2000)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/51001139
Popis: The E- and Z- phosphonoalkenyl acyclonucleosides of uracil and thymine were synthesized under Michael addition conditions. Introduction of an alkyl, alkenyl or alkynyl group at the N-3 position of the pyrimidine moiety was accomplished using potassium carbonate in DMF.
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