| Autor: |
Xiongqi Ding, Catherine Robbe-Masselot, Xiali Fu, Renaud Léonard, Benjamin Marsac, Charlene J. G. Dauriat, Agathe Lepissier, Héloïse Rytter, Elodie Ramond, Marion Dupuis, Daniel Euphrasie, Iharilalao Dubail, Cécile Schimmich, Xiaoquan Qin, Jessica Parraga, Maria Leite-de-Moraes, Agnes Ferroni, Benoit Chassaing, Isabelle Sermet-Gaudelus, Alain Charbit, Mathieu Coureuil, Anne Jamet |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-023-43863-2 |
| Popis: |
Abstract Staphylococcus aureus is a predominant cause of chronic lung infections. While the airway environment is rich in highly sialylated mucins, the interaction of S. aureus with sialic acid is poorly characterized. Using S. aureus USA300 as well as clinical isolates, we demonstrate that quorum-sensing dysfunction, a hallmark of S. aureus adaptation, correlates with a greater ability to consume free sialic acid, providing a growth advantage in an air-liquid interface model and in vivo. Furthermore, RNA-seq experiment reveals that free sialic acid triggers transcriptional reprogramming promoting S. aureus chronic lifestyle. To support the clinical relevance of our results, we show the co-occurrence of S. aureus, sialidase-producing microbiota and free sialic acid in the airway of patients with cystic fibrosis. Our findings suggest a dual role for sialic acid in S. aureus airway infection, triggering virulence reprogramming and driving S. aureus adaptive strategies through the selection of quorum-sensing dysfunctional strains. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full text from SpringerLink