Deleterious effects of prepubertal corticosterone treatment on rat prostate

Autor: Flávia Cristina Morone Pinto, Dílson Silva, Pamella Campos Silva, Luiza Morone Pereira, Arlene Regina Morone, Waldemar Silva Costa, Célia Martins Cortez, Francisco José Barcellos Sampaio
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Acta Cirúrgica Brasileira, Vol 30, Iss 6, Pp 382-387 (2015)
Druh dokumentu: article
ISSN: 0102-8650
DOI: 10.1590/S0102-865020150060000002
Popis: PURPOSE:To investigate the structural and functional changes induced by corticosterone (CORT) in the ventral prostrate (VP) of rats in order to study chronic stress effects in the prepubertal phase.METHODS:Wistar rats received daily saline or CORT injections during the pubertal period from the 5th to 25th day of postnatal life. The animals were distributed into four groups: 1 - Control (n=5); 2 - Control 99mTc-P (n=5); 3 - Treated with CORT (n=14); 4 - Treated with CORT and 99mTc-P (n=10). All rats were sacrificed at two months of age. Technical tissue uptakes of 99mTc-P were used to evaluate the functional and stereological methods for morphological analysis.RESULTS:Acini distribution in the group treated with CORT differed significantly (p
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