INJECTING DRUG USE AS A FACTOR CONTRIBUTES TO HIV-INFECTION
| Autor: | Е. P. Stanko, S. A. Lyalikov, S. A. Igumnov, V. M. Cyrkunov, N. V. Matievskya |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Медицинский вестник Юга России, Vol 0, Iss 1, Pp 86-90 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2219-8075 2618-7876 |
| DOI: | 10.21886/2219-8075-2015-1-86-90 |
| Popis: | Purpose: to determine the nature of the impact of injecting drug use on cellular immunity and assessment of the importance of drug use as a factor contributing to HIV infection and aff ect the course of disease in HIV- positive patients.Materials and methods: surveyed 144 people - 109 patients with drug addiction, HIV infection and HIV - positive injecting drug users and 35 healthy individuals.Results: found that injecting drug potentiates caused by HIV infection decrease the percentage of helper cells ( CD4 + lymphocytes ), natural killer T (CD3 +16 +56 + lymphocytes), natural killer cells (CD3- 16 +56 + cells ), increased cytotoxic T lymphocytes (CD8 + lymphocytes), the proportion and absolute number of T- lymphocyte activation characteristics (CD3 + HLA-DR + cells).Summary: injecting drug use increases the risk of infection among injecting drug users (IDUs) without HIV, and decreases the antiviral response in HIV- positive patients, a statistically signifi cant potentiating caused by HIV in the blood decrease in helper cells, and natural killer T- natural, regulatory cells, immune hyperactivation that contributes to the progression of the disease. |
| Databáze: | Directory of Open Access Journals |
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