Emerging applications in mass spectrometry imaging; enablers and roadblocks
| Autor: | Cristina Russo, Cameron Heaton, Lucy Flint, Oana Voloaca, Sarah Haywood-Small, Malcolm Ronald Clench, Simona Francese, Laura Margaret Cole |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
mass spectrometry imaging (maldi)
secondary ionisation mass spectrometry (sims) desorption electrospray ionisation (desi) laser ablation inductively coupled plasma (la-icp) liquid extraction surface analysis (lesa) imaging mass cytometry (imc) biomolecular imaging technical advancements imaging software Analytical chemistry QD71-142 |
| Zdroj: | Journal of Spectral Imaging, Vol 9, Iss 1, p a13 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2040-4565 |
| DOI: | 10.1255/jsi.2020.a13 |
| Popis: | Mass spectrometry imaging (MSI) is a powerful and versatile technique able to investigate the spatial distribution of multiple non-labelled endogenous and exogenous analytes simultaneously, within a wide range of samples. Over the last two decades, MSI has found widespread application for an extensive range of disciplines including pre-clinical drug discovery, clinical applications and human identification for forensic purposes. Technical advances in both instrumentation and software capabilities have led to a continual increase in the interest in MSI; however, there are still some limitations. In this review, we discuss the emerging applications in MSI that significantly impact three key areas of mass spectrometry (MS) research—clinical, pre-clinical and forensics—and roadblocks to the expansion of use of MSI in these areas. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|