Licochalcone A Induces Ferroptosis in Hepatocellular Carcinoma via Reactive Oxygen Species Activated by the SLC7A11/GPX4 Pathway

Autor: Jin-Xin Zhang Master’s, Yan Xiao Master’s, Yi-Quan Li PhD, Yi-Long Zhu PhD, Ya-Ru Li PhD, Ren-Shuang Zhao Master’s, Ning-Yi Jin PhD, Jin-Bo Fang PhD, Xiao Li PhD, Ji-Cheng Han PhD
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Integrative Cancer Therapies, Vol 22 (2023)
Druh dokumentu: article
ISSN: 1552-695X
15347354
DOI: 10.1177/15347354231210867
Popis: Liver cancer is a common malignant tumor, and its incidence is increasing yearly. Millions of people suffer from liver cancer annually, which has a serious impact on global public health security. Licochalcone A (Lico A), an important component of the traditional Chinese herb licorice, is a natural small molecule drug with multiple pharmacological activities. In this study, we evaluated the inhibitory effects of Lico A on hepatocellular carcinoma cell lines (HepG2 and Huh-7), and explored the inhibitory mechanism of Lico A on hepatocellular carcinoma. First, we evaluated the inhibitory effects of Lico A on hepatocellular carcinoma, and showed that Lico A significantly inhibited and killed HepG2 and Huh-7 cells in vivo and in vitro. Transcriptomic analysis showed that Lico A inhibited the expression of solute carrier family 7 member 11 (SLC7A11), which induced ferroptosis. We confirmed through in vivo and in vitro experiments that Lico A promoted ferroptosis in hepatocellular carcinoma cells by downregulating SLC7A11 expression, thereby inhibiting the glutathione (GSH)-glutathione peroxidase 4 (GPX4) pathway and inducing activation of reactive oxygen species (ROS). In this study, we suggest that Lico A is a potential SLC7A11 inhibitor that induces ferroptotic death in hepatocellular carcinoma cells, thereby providing a theoretical basis for the development of natural small molecule drugs against hepatocellular carcinoma.
Databáze: Directory of Open Access Journals
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