Cerebrospinal fluid efflux through dynamic paracellular pores on venules as a missing piece of the brain drainage system
| Autor: | Yaqiong Dong, Ting Xu, Lan Yuan, Yahan Wang, Siwang Yu, Zhi Wang, Shizhu Chen, Chunhua Chen, Weijiang He, Tessandra Stewart, Weiguang Zhang, Xiaoda Yang |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Exploration, Vol 4, Iss 2, Pp n/a-n/a (2024) |
| Druh dokumentu: | article |
| ISSN: | 2766-2098 2766-8509 |
| DOI: | 10.1002/EXP.20230029 |
| Popis: | Abstract The glymphatic system plays a key role in the clearance of waste from the parenchyma, and its dysfunction has been associated with the pathogenesis of Alzheimer's disease (AD). However, questions remain regarding its complete mechanisms. Here, we report that efflux of cerebrospinal fluid (CSF)/interstitial fluid (ISF) solutes occurs through a triphasic process that cannot be explained by the current model, but rather hints at the possibility of other, previously undiscovered routes from paravenous spaces to the blood. Using real‐time, in vivo observation of efflux, a novel drainage pathway was discovered, in which CSF molecules enter the bloodstream directly through dynamically assembled, trumpet‐shaped pores (basolateral ϕ |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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