| Autor: |
Erica C. Heinrich, Jeremy E. Orr, Dillon Gilbertson, Cecilia Anza-Ramirez, Pamela N. DeYoung, Matea A. Djokic, Noemi Corante, Gustavo Vizcardo-Galindo, Jose L. Macarlupu, Eduardo Gaio, Frank L. Powell, Atul Malhotra, Francisco C. Villafuerte, Tatum S. Simonson |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Frontiers in Physiology, Vol 11 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1664-042X |
| DOI: |
10.3389/fphys.2020.00437 |
| Popis: |
Andean highlanders are challenged by chronic hypoxia and many exhibit elevated hematocrit (Hct) and blunted ventilation compared to other high-altitude populations. While many Andeans develop Chronic Mountain Sickness (CMS) and excessive erythrocytosis, Hct varies markedly within Andean men and women and may be driven by individual differences in ventilatory control and/or sleep events which exacerbate hypoxemia. To test this hypothesis, we quantified relationships between resting ventilation and ventilatory chemoreflexes, sleep desaturation, breathing disturbance, and Hct in Andean men and women. Ventilatory measures were made in 109 individuals (n = 63 men; n = 46 women), and sleep measures in 45 of these participants (n = 22 men; n = 23 women). In both men and women, high Hct was associated with low daytime SpO2 (p < 0.001 and p < 0.002, respectively) and decreased sleep SpO2 (mean, nadir, and time |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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