Autor: |
Kayla Vidinopoulos, Zahrah Azman, Ainsley Somers, Valerie A. Zahra, Alison Thiel, Hui Lu, Yen Pham, Nhi Thao Tran, Beth J. Allison, Eric Herlenius, Stuart Hooper, Robert Galinsky, Graeme R. Polglase |
Jazyk: |
angličtina |
Rok vydání: |
2023 |
Předmět: |
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Zdroj: |
Frontiers in Pediatrics, Vol 11 (2023) |
Druh dokumentu: |
article |
ISSN: |
2296-2360 |
DOI: |
10.3389/fped.2023.1225294 |
Popis: |
BackgroundPreterm infants have immature respiratory drive and often require prolonged periods of mechanical ventilation. Prolonged mechanical ventilation induces systemic inflammation resulting in ventilation-induced brain injury, however its effect on brainstem respiratory centers is unknown. We aimed to determine the effects of 24 h of mechanical ventilation on inflammation and injury in brainstem respiratory centres of preterm fetal sheep.MethodsPreterm fetal sheep at 110 ± 1 days (d) gestation were instrumented to provide mechanical ventilation in utero. At 112 ± 1 d gestation, fetuses received either mechanical ventilation (VENT; n = 7; 3 ml/kg) for 24 h, or no ventilation (CONT; n = 6). At post-mortem, fetal brainstems were collected for assessment of mRNA and histological markers of inflammation and injury.ResultsIn utero ventilation (IUV) did not alter any blood-gas parameters. IUV significantly increased systemic IL-6 and IL-8 concentrations over the 24 h period compared to CONT. The number of ameboid microglia within the nucleus tractus solitarius and the raphe nucleus increased in VENT fetuses (p |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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