Natural infection as a blueprint for rational HIV vaccine design

Autor:	Marlies M. van Haaren, Tom L. G. M. van den Kerkhof, Marit J. van Gils
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	broadly neutralizing antibodies co-evolution envelope glycoprotein hiv-1 vaccine Immunologic diseases. Allergy RC581-607 Therapeutics. Pharmacology RM1-950
Zdroj:	Human Vaccines & Immunotherapeutics, Vol 13, Iss 1, Pp 229-236 (2017)
Druh dokumentu:	article
ISSN:	2164-5515 2164-554X 21645515
DOI:	10.1080/21645515.2016.1232785
Popis:	So far, the development of a human immunodeficiency virus (HIV) vaccine has been unsuccessful. However, recent progress in the field of broadly neutralizing antibodies (bNAbs) has reinvigorated the search for an HIV vaccine. bNAbs develop in a minority of HIV infected individuals and passive transfer of these bNAbs to non-human primates provides protection from HIV infection. Studies in a number of HIV infected individuals on bNAb maturation alongside viral evolution and escape have shed light on the features important for bNAb elicitation. Here we review the observations from these studies, and how they influence the rational design of HIV vaccines.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/cc68d198df7d419196d732a9d7dc3761 Zobrazit plný text záznamu View record in DOAJ