| Autor: |
Katarina Mirković, Carolina R C Doorenbos, Wendy A Dam, Hiddo J Lambers Heerspink, Maartje C J Slagman, Ferdau L Nauta, Andrea B Kramer, Ronald T Gansevoort, Jacob van den Born, Gerjan Navis, Martin H de Borst |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 8, Iss 2, p e55887 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0055887 |
| Popis: |
Non-invasive tubulointerstitial damage markers may allow better titration and monitoring of renoprotective therapy. We investigated the value of urinary vitamin D binding protein excretion (uVDBP) as a tubulointerstitial inflammation and fibrosis marker in adriamycin rats, and tested whether uVDBP parallels renal damage and responds to therapy intensification in humans. In adriamycin (ADR) rats, uVDBP was strongly elevated vs controls (CON) already 6 wks after nephrosis induction (ADR: 727±674 [mean±SD] vs CON: 9±12 µg/d, p100-fold increased during maximal therapy vs normoalbuminurics (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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