Osteoinductive effect of the nanoparticulate form of Cissus quadrangularis ethanolic extract on implant surface in experimental animals

Autor: Shilpa S. Prabhu, I. N. Aparna, Srinivas Mutalik, Saleemulla Khan, Shobha Kamath, Raghu Radhakrishnan, Dhanasekar Balakrishnan, Ajjappla B. Shreya, Tejal D. Durgekar
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Beni-Suef University Journal of Basic and Applied Sciences, Vol 13, Iss 1, Pp 1-17 (2024)
Druh dokumentu: article
ISSN: 2314-8543
DOI: 10.1186/s43088-024-00463-3
Popis: Abstract Background The purpose of this study was to evaluate the effect of nanoparticles (NPs) of a plant extract on implant osseointegration in vivo. NPs of the Cissus quadrangularis (CQ) extract were synthesized. Twenty Wistar rats were included in the study. The test group (n = 5) had NPs-incorporated, the control group (n = 5) had no incorporation of NPs, and the sham group (n = 5) did not have implants placed. The toxicity profile of NPs was carried out by biochemical analysis before and after the implant placement. The rate of integration was assessed using Cone Beam Computed Tomography (CBCT), Digital X-ray, histology, and scanning electron microscopy (SEM) at intervals of 2, 4, and 6 weeks. Statistical significance between the groups was determined by Analysis of Variance (ANOVA) (p
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