Synthesis, Characterization and Antifungal Activity of Some Substituted 4-thiazolidinone Derivatives

Autor: Hamdan Salameh Al-Ebaisat, Taher Sharif Ababne, Tareq Mousa Al Shboul, Taghreed M. Jazzazi
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Journal of Pure and Applied Chemistry Research, Vol 5, Iss 3, Pp 125-130 (2016)
Druh dokumentu: article
ISSN: 2302-4690
DOI: 10.21776/ub.jpacr.2016.005.03.248
Popis: A series of 4-thiazolidinone derivatives was prepared including 2- (4-phenyl)-3-(4-hydroxyphenyl)thiazolidinone-4-one (1), 2-(4-bromophenyl)-3-(4-hydroxy phenyl) thiazolidinone-4-one (2), 2-(4-chlorophenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one (3), 2-(4-methylphenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one (4), 2-(4-metoxyphenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one (5), 2-(4-nitrophenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one (6), 2,3-bis(4-hydroxyphenyl) thiazolidinone-4-one (7) and 2-(4-ethyl phenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one (8). The chemical structures of prepared compounds have been characterized by Mass, IR, 1H-NMR, and elemental analyses. The biological activity of these compounds as fungicides was tested against three commercially known fungicides (C. albicans, patient isolate C. glabrata and C. krusei). The biological activity of compound (6) was found to be comparable to that of the commercially available fungicides.
Databáze: Directory of Open Access Journals