| Autor: |
Manuel Méndez-Bailón, Rodrigo Jiménez-García, Valentín Hernández-Barrera, Javier de Miguel-Díez, José M. de Miguel-Yanes, Nuria Muñoz-Rivas, Noel Lorenzo-Villalba, David Carabantes-Alarcon, José J. Zamorano-León, Paloma Astasio-Arbiza, Paloma Ortega-Molina, Ana López-de-Andrés |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Journal of Clinical Medicine, Vol 9, Iss 3, p 614 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2077-0383 |
| DOI: |
10.3390/jcm9030614 |
| Popis: |
Background: We aimed to (1) analyze time trends in the incidence and in-hospital outcomes of heart failure (HF) patients suffering Clostridioides difficile infection (CDI); (2) compare clinical characteristics of CDI patients between those with HF and matched non-HF patients; and (3) identify predictors of in-hospital mortality (IHM) among HF patients suffering CDI. Methods: Retrospective study using the Spanish National Hospital Discharge Database from 2001 to 2015. Patients of age ≥40 years with CDI were included. For each HF patient, we selected a year, age, sex, and readmission status-matched non-HF patient. Results: We found 44,695 patients hospitalized with CDI (15.46% with HF). HF patients had a higher incidence of CDI (202.05 vs. 145.09 per 100,000 hospitalizations) than patients without HF (adjusted IRR 1.35; 95% CI 1.31−1.40). IHM was significantly higher in patients with HF when CDI was coded as primary (18.39% vs. 7.63%; p < 0.001) and secondary diagnosis (21.12% vs. 14.76%; p < 0.001). Among HF patient’s predictor of IHM were older age (OR 8.80; 95% CI 2.55−20.33 for ≥85 years old), those with more comorbidities (OR 1.68; 95% CI 1.12−2.53 for those with Charlson Comorbidity index ≥2), and in those with severe CDI (OR 6.19; 95% CI 3.80−10.02). Conclusions: This research showed that incidence of CDI was higher in HF than non-HF patients. HF is a risk factor for IHM after suffering CDI. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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