Peripheral biomarkers of oxidative stress in dogs with acute pancreatitis

Autor: Nicole V. Tusa, Angel Abuelo, Nyssa A. Levy, Jeffery C. Gandy, Daniel K. Langlois, Harry Cridge
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Veterinary Internal Medicine, Vol 36, Iss 6, Pp 1958-1965 (2022)
Druh dokumentu: article
ISSN: 1939-1676
0891-6640
DOI: 10.1111/jvim.16535
Popis: Abstract Background Oxidative stress is considered a pathomechanism of acute pancreatitis (AP), but no studies have extensively characterized oxidant status in dogs with naturally‐occurring AP. Hypothesis or Objectives Evaluate measures of oxidant status in dogs with AP and explore whether these measures correlate with AP severity. Animals Fifteen dogs with AP and 9 control dogs. Methods Prospective, controlled observational study. Plasma reactive metabolite (RM) concentrations, antioxidant potential (AOP), and urinary F2 isoprostane concentrations were measured in AP dogs and healthy controls. Severity of AP was assessed by length of hospitalization and 3 disease severity indices: canine acute pancreatitis severity (CAPS), modified canine activity index (M‐CAI), and the acute patient physiologic and laboratory evaluation score (APPLEfull). Results Reactive metabolite (RM) concentrations (median, 65 relative fluorescent units [RFU]/μL; range, 20‐331 RFU/μL) and RM:AOP (median, 7; range, 4‐109) were higher in AP dogs than healthy controls (median RM, 25 RFU/μL; range, 16‐41 RFU/μL; median RM:AOP, 4; range, 2‐7; P
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