| Autor: |
Timothy B. Nguyen, Jane M. Gunn, Maria Potiriadis, Ian P. Everall, Chad A. Bousman |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
BJPsych Open, Vol 1, Pp 104-109 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
2056-4724 |
| DOI: |
10.1192/bjpo.bp.115.000380 |
| Popis: |
Background Cross-sectional studies suggest that the serotonin transporter promoter region polymorphism (5-HTT gene-linked polymorphic region, 5HTTLPR) moderates the relationship between childhood abuse and major depressive disorder. Aims To examine whether the 5HTTLPR polymorphism moderates the effect childhood abuse has on 5-year depressive symptom severity trajectories in adulthood. Method At 5-year follow-up, DNA from 333 adult primary care attendees was obtained and genotyped for the 5HTTLPR polymorphism. Linear mixed models were used to test for a genotype × childhood abuse interaction effect on 5-year depressive symptom severity trajectories. Results After covariate adjustment, homozygous s allele carriers with a history of severe childhood abuse had significantly greater depressive symptom severity at baseline compared with those without a history of severe childhood abuse and this effect persisted throughout the 5-year period of observation. Conclusions The 5HTTLPR s/s genotype robustly moderates the effects of severe childhood abuse on depressive symptom severity trajectories in adulthood. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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