Kinesin-14 motors drive a right-handed helical motion of antiparallel microtubules around each other

Autor: Aniruddha Mitra, Laura Meißner, Rojapriyadharshini Gandhimathi, Roman Renger, Felix Ruhnow, Stefan Diez
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-16328-z
Popis: Some kinesins exhibit off-axis power strokes but their impact on motility and force generation in microtubule overlaps has not been investigated so far. Here authors use a 3D in vitro motility assay and find that Ndc’s off-axis motor forces generate torque in antiparallel microtubules which causes microtubule twisting and coiling.
Databáze: Directory of Open Access Journals