| Autor: |
Amina Khatun, Mahmudur Rahman, Mst. Luthfun Nesa, Chung Yeng Looi, Won Fen Wong, Hazrina Hazni, Mohamad Azrul bin Mahdzir, Shaikh Jamal Uddin, Khalijah Awang, Jamil A. Shilpi |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Clinical Phytoscience, Vol 8, Iss 1, Pp 1-9 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2199-1197 |
| DOI: |
10.1186/s40816-022-00340-5 |
| Popis: |
Abstract Background Cestrum diurnum L. (Solanaceae), locally known as buno-Hasnahena, is widely used in different traditional medicinal practices to treat pain, burn, swelling and related disorders. Adequate evidence is not available to support its medicinal properties for further use and drug development. Present study was designed to evaluate its traditional use in pain and inflammation with further characterisation of its chemical constituents through liquid chromatography-mass spectroscopic (LC-MS) analysis. Methods Antinociceptive and analgesic potential of methanol extract of the aerial parts of C. diurnum was carried out using carrageenan induced paw oedema and formalin induced paw licking test in mice at the oral doses of 150 and 300 mg/kg body weight. Inhibition of the inflammatory mediator nuclear factor kappa B (NF-κB) was evaluated by tumour necrosis factor α (TNF-α) induced NF-κB activation assay in macrophage cells at the concentration of 100 μg/ml. LC-MS analysis of the extract was performed to characterise the active component responsible for bioactivities. Results The extract significantly inhibited (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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