| Autor: |
Seyed Ali Hosseinian, Jamshid Mehrzad, Seyed Reza Mirhafez, Jafar Saeidi, Rahele Zhiani, Amirhossein Sahebkar |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 96, Iss , Pp 105202- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2022.105202 |
| Popis: |
Introduction: The aim of this study was to evaluate the effects of the phytosomal curcuminoids on oxidative stress and inflammatory biomarkers along with routine biochemical factors in non-alcoholic fatty liver disease (NAFLD). Methods: Seventy-two patients were selected and randomly divided into Placebo and Curcumin groups (250 mg of phytosomal curcuminoids daily for two months). Biochemical, inflammatory biomarkers including interleukin (IL) 6, IL-10, TNFα (tumor necrosis factor alpha), MCP-1 (monocyte chemoattractant protein-1) and high-sensitivity C-reactive protein (hsCRP) and oxidative stress measurements including malondialdehyde (MDA), superoxide dismutase (SOD) and Catalase (CAT) were measured between two groups before and after the intervention. Results: Curcumin treatment statistically significant increased the activity of CAT enzyme compared with the Placebo group after intervention (p value = 0.001). However, no significant changes were observed in MDA and SOD biomarkers. Moreover, there was a statistically significant reduction in monocyte chemoattractant protein-1 (MCP-1) levels as a chemokine in the Curcumin group compared with the Placebo group after treatment (p value = 0.007). Conclusion: Daily use of 250 mg of phytosomal curcuminoids for two months in patients with NAFLD resulted in a significant increase of CAT activity and a significant reduction of MCP-1. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect