Assessment of mutagenicity and cytotoxicity of Solanum paniculatum L. extracts using in vivo micronucleus test in mice

Autor:	PM. Vieira, SC. Santos, L. Chen-Chen
Jazyk:	angličtina
Předmět:	mutagenicity cytotoxicity Solanum paniculatum L. micronucleus mice Science Biology (General) QH301-705.5 Zoology QL1-991 Botany QK1-989
Zdroj:	Brazilian Journal of Biology, Vol 70, Iss 3, Pp 601-606
Druh dokumentu:	article
ISSN:	1678-4375 1519-6984
DOI:	10.1590/S1519-69842010000300017
Popis:	Solanum paniculatum L. is a plant species widespread throughout tropical America, especially in the Brazilian Savanna region. It is used in Brazil for culinary purposes and in folk medicine to treat liver and gastric dysfunctions, as well as hangovers. Because of the wide use of this plant as a therapeutic resource and food, the present study aimed at evaluating the mutagenic and cytotoxic effects of S. paniculatum ethanolic leaf and fruit extracts using the mouse bone marrow micronucleus test. Our results indicate that neither S. paniculatum ethanolic leaf extract nor its ethanolic fruit extract exhibited mutagenic effect in mice bone marrow; however, at higher doses, both extracts presented cytotoxic activity.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/68923b363144455d8473ba52f7abf60b Zobrazit plný text záznamu View record in DOAJ