Activation of the cellular mitogen-activated protein kinase pathways ERK, P38 and JNK during Toxoplasma gondii invasion

Autor:	Valère A., Garnotel R., Villena I., Guenounou M., Pinon J.M., Aubert D.
Jazyk:	angličtina
Rok vydání:	2003
Předmět:	Toxoplasma gondii human monocytic cell (THP1) MAP kinases phosphorylation Infectious and parasitic diseases RC109-216
Zdroj:	Parasite, Vol 10, Iss 1, Pp 59-64 (2003)
Druh dokumentu:	article
ISSN:	1252-607X 1776-1042
DOI:	10.1051/parasite/2003101p59
Popis:	Host cell invasion is essential for the pathogenicity of the obligate intracellular protozoan parasite Toxoplasma gondii. In the present study, we evaluated the ability of T. gondii tachyzoites to trigger phosphorylation of the different mitogen-activated protein kinases (MAPK) in human monocytic cells THP1. Kinetic experiments show that the peak of extracellular-signal-regulated kinase (ERK 1/2), P38 and cjun-NH2 terminal kinase (JNKs) phosphorylation occurs between 10 and 60 min. The use of specific inhibitors of ERK1/2, P38 and JNK1/2 phosphorylation indicates the specificity of MAPKs phosphorylation during invasion. Signaling through cellular and parasite mitogen-activated protein (MAP) kinase pathways appears to be critical for T. gondii invasion.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/68902a1c382a492dbc5e210dc7dae05b Zobrazit plný text záznamu View record in DOAJ