Combination versus single-agent as palliative chemotherapy for gastric cancer

Autor:	Jin-Hyuk Choi, Yong Won Choi, Seok Yun Kang, Geum Sook Jeong, Hyun Woo Lee, Seong Hyun Jeong, Joon Seong Park, Mi Sun Ahn, Seung Soo Sheen
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Gastric cancer Palliative chemotherapy Single Combination Platelet-to-lymphocyte ratio Age Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
Druh dokumentu:	article
ISSN:	1471-2407
DOI:	10.1186/s12885-020-6666-1
Popis:	Abstract Background Although combination chemotherapy (CC) is generally recommended in recurrent or primary metastatic gastric cancer (RPMGC), the results of randomized trials are conflicting. Methods A retrospective review was conducted on 687 RPMGC patients who received palliative chemotherapy. We compared the overall survival (OS) between CC and single-agent chemotherapy (SC) among these patients, and we analyzed the clinicopathological characteristics affecting outcome including neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). Results Although 521 patients (75.8%) underwent CC, SC was more frequently performed in elderly patients (57.6%) and ECOG performance status (PS) 2 or 3 (65.8%) patients (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/cd68838292f94f4797ed4a90c81c76ee Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.