Canine adenovirus type 1 causing neurological signs in a 5-week-old puppy

Autor: Samuel J. Hornsey, Hélène Philibert, Dale L. Godson, Elisabeth C. R. Snead
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: BMC Veterinary Research, Vol 15, Iss 1, Pp 1-6 (2019)
Druh dokumentu: article
ISSN: 1746-6148
25196014
DOI: 10.1186/s12917-019-2173-5
Popis: Abstract Background Infectious canine hepatitis is a rarely encountered disease, that is caused by Canine Adenovirus-1. Clinical signs can vary dramatically, and neurological signs are rarely seen. Neurological manifestation of this disease is rarely reported in the veterinary literature. Case presentation A 5-week-old, male entire Husky cross puppy presented for a one-day history of abnormal neurological behaviour (circling, ataxia, vocalization and obtund mentation). The puppy was euthanized shortly after presentation due to rapid deterioration. Histopathology raised concerns for Canine Adenovirus 1 (CAdV-1) based on vasculitis in the brain and intranuclear inclusion bodies in endothelial cell and hepatocytes; immunohistochemistry on brain tissue confirmed CAdV-1 infection. Conclusions This report discusses possible routes of infection and manifestations of adenovirus infections causing neurologic signs. It also provides a timely reminder that CAdV-1 should be considered a differential in unvaccinated dogs that present with neurological signs. Further studies are required to better understand the neurotrophic tendencies of this virus.
Databáze: Directory of Open Access Journals
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