Identification of new major histocompatibility complex-B Haplotypes in Bangladesh native chickens

Autor: Thisarani Kalhari Ediriweera, Prabuddha Manjula, Jaewon Kim, Jin Hyung Kim, Seonju Nam, Minjun Kim, Eunjin Cho, Mohammad Shamsul Alam Bhuiyan, Md. Abdur Rashid, Jun Heon Lee
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Animal Bioscience, Vol 37, Iss 5, Pp 826-831 (2024)
Druh dokumentu: article
ISSN: 2765-0189
2765-0235
DOI: 10.5713/ab.23.0295
Popis: Objective The major histocompatibility complex in chicken demonstrates a great range of variations within varities, breeds, populations and that can eventually influence their immuneresponses. The preset study was conducted to understand the major histocompatibility complex-B (MHC-B) variability in five major populations of Bangladesh native chicken: Aseel, Hilly, Junglefowl, Non-descript Deshi, and Naked Neck. Methods These five major populations of Bangladesh native chicken were analyzed with a subset of 89 single nucleotide polymorphisms (SNPs) in the high-density MHC-B SNP panel and Kompetitive Allele-Specific polymerase chain reaction genotyping was applied. To explore haplotype diversity within these populations, the results were analyzed both manually and computationally using PHASE 2.1 program. The phylogenetic investigations were also performed using MrBayes program. Results A total of 136 unique haplotypes were identified within these five Bangladesh chicken populations, and only one was shared (between Hilly and Naked Neck). Phylogenetic analysis showed no distinct haplotype clustering among the five populations, although they were shared in distinct clades; notably, the first clade lacked Naked Neck haplotypes. Conclusion The present study discovered a set of unique MHC-B haplotypes in Bangladesh chickens that could possibly cause varied immune reponses. However, further investigations are required to evaluate their relationships with global chicken populations.
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