The therapeutic dilemma of immunosuppressive drugs for refractory cardiac sarcoidosis in COVID‐19 infection

Autor: Kohsaku Goto, Masae Uehara, Koh Okamoto, Norifumi Takeda, Hiroyuki Morita, Masaru Hatano, Issei Komuro
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: ESC Heart Failure, Vol 8, Iss 6, Pp 5577-5582 (2021)
Druh dokumentu: article
ISSN: 2055-5822
68451385
DOI: 10.1002/ehf2.13676
Popis: Abstract Patients with refractory cardiac sarcoidosis (CS) take a high dose of corticosteroid and immunosuppressive agents. During the pandemic outbreak of severe acute respiratory syndrome coronavirus 2, appropriate treatment of corticosteroids or immunosuppressive agents in CS patients with coronavirus disease 2019 (COVID‐19) is unknown. Here, the woman with refractory CS receiving maintenance therapy with 15 mg of prednisolone daily and 10 mg of methotrexate weekly was emergently admitted to our hospital because of COVID‐19. This case was successfully treated by the intravenous administration of dexamethasone 6 mg/day instead of prednisolone and interruption of methotrexate without resulting in recurrent life‐threatening ventricular lethal arrhythmias or obvious sarcoidosis flare‐ups. She started taking prednisolone and methotrexate at the maintenance dose immediately and at 2 weeks after discharge, respectively. Although the optimal regimen of immunosuppressive agents during COVID‐19 is under intense debate, this report might provide an effective treatment strategy for CS patients with COVID‐19.
Databáze: Directory of Open Access Journals
Externí odkaz: