Maximum 11C-methionine PET uptake as a prognostic imaging biomarker for newly diagnosed and untreated astrocytic glioma

Autor: Kosuke Nakajo, Takehiro Uda, Toshiyuki Kawashima, Yuzo Terakawa, Kenichi Ishibashi, Naohiro Tsuyuguchi, Yuta Tanoue, Atsufumi Nagahama, Hiroshi Uda, Saya Koh, Tsuyoshi Sasaki, Kenji Ohata, Yonehiro Kanemura, Takeo Goto
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-021-04216-5
Popis: Abstract This study aimed whether the uptake of amino tracer positron emission tomography (PET) can be used as an additional imaging biomarker to estimate the prognosis of glioma. Participants comprised 56 adult patients with newly diagnosed and untreated World Health Organization (WHO) grade II–IV astrocytic glioma who underwent surgical excision and were evaluated by 11C-methionine PET prior to the surgical excision at Osaka City University Hospital from July 2011 to March 2018. Clinical and imaging studies were retrospectively reviewed based on medical records at our institution. Preoperative Karnofsky Performance Status (KPS) only influenced progression-free survival (hazard ratio [HR] 0.20; 95% confidence interval [CI] 0.10–0.41, p
Databáze: Directory of Open Access Journals
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