BRCA1 and TOP2A gene amplification and protein expression in four molecular subtypes of breast cancer

Autor: Mitrović Olivera, Mićić Mileva, Čokić V., Koko Vesna, Đikić Dragoslava, Budeč Mirela, Vignjević Sanja, Breković Tijana
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Archives of Biological Sciences, Vol 65, Iss 2, Pp 511-518 (2013)
Druh dokumentu: article
ISSN: 0354-4664
1821-4339
DOI: 10.2298/ABS1302511M
Popis: We studied TOP2A amplification (using FISH methods), and TOP2A and BRCA1 protein overexpression (immunohistochemistry) in four molecular subtypes of breast cancer. Of 53 patients, 32 showed TOP2A and 38 showed BRCA1 overexpression. The highest percentage of TOP2A amplification (47.8%) and deletion (13%) was detected in Luminal B subtypes. Of 11 Luminal B tumors with TOP2A amplification, 9 (81.8%) overexpressed TOP2A. BRCA1 protein overexpression showed significant positive correlation with TOP2A protein expression. BRCA1 and TOP2A proteins exhibited similar patterns of expression in Luminal B and triple-negative breast cancer, suggesting the same prognosis in those patients. [Projekat Ministarstva nauke Republike Srbije, br. 175053]
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