| Autor: |
Esther Osher, Ravit Geva, Ido Wolf, Karen Tordjman, Joseph Klausner, Yael Sofer, Erez Scapa, Oren Shibolet, Dana Ben –Ami Shor, Iddo Bar-Yishay, Nir Lubezky, Yaacov Goykhman, Guy Lahat, Oz Yakir, Sharon Pelles, Asaf Aizic, Arye Blachar, Naftali Stern, Yona Greenman |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of Clinical & Translational Endocrinology, Vol 33, Iss , Pp 100322- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2214-6237 |
| DOI: |
10.1016/j.jcte.2023.100322 |
| Popis: |
Objective: Pancreatic neuroendocrine tumors (PNETs) are rare, but their incidence has risen significantly in recent years. Whereas diabetes mellitus (DM) is recognized in association with chronic pancreatitis and pancreatic cancer, it has not been well-characterized concerning non-functioning (NF)-PNETs.Study aim: to determine whether NF-PNETs are associated with DM/ Pre-DM and characterize the features of this putative association. Methods: Retrospective study to evaluate rate of Pre-DM /DM in subjects with NF-PNETs. Results: Study cohort of 129 patients with histologically confirmed NF-PNETs, ∼60% were men (M/F: 77/52). Abnormal glucose metabolism that preceded any treatment was seen in 70% of this cohort: overt DM in 34% and Pre-DM in 36% of the subjects. However, during follow-up, the overall prevalence rose to 80.6%, owing exclusively to newly diagnosed DM in subjects who received treatment.Patients with DM/Pre-DM were older (65 ± 11; 54 ± 14; p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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