Molecular Pathogenesis and the Possible Role of Mitochondrial Heteroplasmy in Thoracic Aortic Aneurysm

Autor:	A. V. Suslov, M. A. Afanasyev, P. A. Degtyarev, P. V. Chumachenko, M. Bagheri Ekta, V. N. Sukhorukov, V. A. Khotina, S.-F. Yet, I. A. Sobenin, A. Yu Postnov
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	thoracic aortic aneurysm mitochondrial genome inflammation metabolism aortic dissection cardiovascular diseases Science
Zdroj:	Life, Vol 11, Iss 12, p 1395 (2021)
Druh dokumentu:	article
ISSN:	2075-1729
DOI:	10.3390/life11121395
Popis:	Thoracic aortic aneurysm (TAA) is a life-threatening condition associated with high mortality, in which the aortic wall is deformed due to congenital or age-associated pathological changes. The mechanisms of TAA development remain to be studied in detail, and are the subject of active research. In this review, we describe the morphological changes of the aortic wall in TAA. We outline the genetic disorders associated with aortic enlargement and discuss the potential role of mitochondrial pathology, in particular mitochondrial DNA heteroplasmy, in the disease pathogenesis.
Databáze:	Directory of Open Access Journals
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