Delayed Disease Progression in Cynomolgus Macaques Infected with Ebola Virus Makona Strain

Autor:	Andrea Marzi, Friederike Feldmann, Patrick W. Hanley, Dana Scott, Stephan Günther, Heinz Feldmann
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	Ebola virus viruses West African Ebola virus isolate Makona strain Ebola hemorrhagic fever nonhuman primates Medicine Infectious and parasitic diseases RC109-216
Zdroj:	Emerging Infectious Diseases, Vol 21, Iss 10, Pp 1777-1783 (2015)
Druh dokumentu:	article
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2110.150259
Popis:	In late 2013, the largest documented outbreak of Ebola hemorrhagic fever started in Guinea and has since spread to neighboring countries, resulting in almost 27,000 cases and >11,000 deaths in humans. In March 2014, Ebola virus (EBOV) was identified as the causative agent. This study compares the pathogenesis of a new EBOV strain, Makona, which was isolated in Guinea in 2014 with the prototype strain from the 1976 EBOV outbreak in the former Zaire. Both strains cause lethal disease in cynomolgus macaques with similar pathologic changes and hallmark features of Ebola hemorrhagic fever. However, disease progression was delayed in EBOV-Makona–infected animals, suggesting decreased rather than increased virulence of this most recent EBOV strain.
Databáze:	Directory of Open Access Journals
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