Single versus repeated tramadol injection in laparotomized albino rats: comparison of effects on hematology, serum biochemical parameters, and body weight gain

Autor: Rita Ijeoma Udegbunam, Henry Nnamdi Okereke, Sunday Ositadimma Udegbunam
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Journal of Advanced Veterinary and Animal Research, Vol 2, Iss 3, Pp 316-320 (2015)
Druh dokumentu: article
ISSN: 2311-7710
DOI: 10.5455/javar.2015.b100
Popis: This study was aimed to assess the effects of single and repeated tramadol administration on some hematological and serum biochemical parameters of laparotomized rats. Laparotomized rats (n=18) were randomly divided into three equal groups. Normal saline was administered to the rats of group 1 (control). Tramadol (dosed at 10 mg/kg bwt) was administered singly to the rats of group 2. The same dose of tramadol was administered repeatedly every 12 h up to 72 h to the rats of group 3. On day 3 and 10 post-laparotomy (PSL), blood urea nitrogen, serum creatinine, total serum protein, hematocrit, hemoglobin concentration and red blood cell counts in the rats of group 2 were found to be significantly (P
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