Peripheral blood cell microRNA quantification during the first trimester predicts preeclampsia: Proof of concept.

Autor:	Edward E Winger, Jane L Reed, Xuhuai Ji, Kypros Nicolaides
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Medicine Science
Zdroj:	PLoS ONE, Vol 13, Iss 1, p e0190654 (2018)
Druh dokumentu:	article
ISSN:	1932-6203
DOI:	10.1371/journal.pone.0190654
Popis:	We investigated the capacity of microRNAs isolated from peripheral blood buffy coat collected late during the first trimester to predict preeclampsia.The cohort study comprised 48 pregnant women with the following pregnancy outcomes: 8 preeclampsia and 40 with normal delivery outcomes. Quantitative rtPCR was performed on a panel of 30 microRNAs from buffy coat samples drawn at a mean of 12.7±0.5 weeks gestation. MicroRNA Risk Scores were calculated and AUC-ROC calculations derived.The AUC-ROC for preeclampsia risk was 0.91 (p
Databáze:	Directory of Open Access Journals
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