Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis

Autor: Alena V. Yermalovich, Jihan K. Osborne, Patricia Sousa, Areum Han, Melissa A. Kinney, Michael J. Chen, Daisy A. Robinton, Helen Montie, Dan S. Pearson, Sean B. Wilson, Alexander N. Combes, Melissa H. Little, George Q. Daley
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-018-08127-4
Popis: Nephrogenesis ceases after postnatal day 2 in the mouse or after the 36th week of gestation in humans, but how this is regulated is unclear. Here, the authors identify a role for the RNA-binding protein Lin28 and suppression of let-7 microRNA in regulating the duration of nephrogenesis.
Databáze: Directory of Open Access Journals