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Heshu Sulaiman Rahman,1,2 Darya Saeed Abdulateef,1 Narmin Hamaamin Hussen,3 Aso Faiq Salih,4 Hemn Hassan Othman,5 Trifa Mahmood Abdulla,1 Shirwan Hama Salih Omer,1 Talar Hamaali Mohammed,1 Mohammed Omar Mohammed,6 Masrur Sleman Aziz,7 Rasedee Abdullah8 1Department of Physiology, College of Medicine, University of Sulaimani, Sulaimaniyah, Republic of Iraq; 2Department of Medical Laboratory Sciences, Komar University of Science and Technology, Sulaimaniyah, Republic of Iraq; 3Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, University of Sulaimani, Sulaimaniyah, Republic of Iraq; 4Department of Pediatrics, College of Medicine, University of Sulaimani, Sulaimaniyah, Republic of Iraq; 5Department of Pharmacology and Toxicology, College of Pharmacy, University of Sulaimani, Sulaimaniyah, Republic of Iraq; 6Department of Medicine, College of Medicine, University of Sulaimani, Sulaimaniyah, Republic of Iraq; 7Department of Biology, College of Education, Salahaddin University, Erbil, Republic of Iraq; 8Faculty of Veterinary Medicine, Universiti Putra Malaysia, UPM, Serdang, Selangor, 43400, MalaysiaCorrespondence: Heshu Sulaiman RahmanDepartment of Physiology, College of Medicine, University of Sulaimani, Sulaimaniyah, 46001, Republic of IraqTel +964 7726159598Email heshu.rhaman@univsul.edu.iqAso Faiq SalihDepartment of Pediatrics, College of Medicine, University of Sulaimani, Sulaimaniyah, Republic of IraqEmail aso.salih@univsul.edu.iqAbstract: Over the last few decades, there have been several global outbreaks of severe respiratory infections. The causes of these outbreaks were coronaviruses that had infected birds, mammals and humans. The outbreaks predominantly caused respiratory tract and gastrointestinal tract symptoms and other mild to very severe clinical signs. The current coronavirus disease-2019 (COVID-19) outbreak, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a rapidly spreading illness affecting millions of people worldwide. Among the countries most affected by the disease are the United States of America (USA), India, Brazil, and Russia, with France recording the highest infection, morbidity, and mortality rates. Since early January 2021, thousands of articles have been published on COVID-19. Most of these articles were consistent with the reports on the mode of transmission, spread, duration, and severity of the sickness. Thus, this review comprehensively discusses the most critical aspects of COVID-19, including etiology, epidemiology, pathogenesis, clinical signs, transmission, pathological changes, diagnosis, treatment, prevention and control, and vaccination.Keywords: recent advancements, COVID-19, pandemic infection, global outbreak, a comprehensive review |
