SODIUM POLYPRENYL PHOSPHATE (PHOSPRENYL) EXERTS AN IL-2-DEPENDENT RESTORATIVE EFFECT UPON IN VIVO DTH INHIBITION
Autor: | S. M. Sobolev, T. N. Nikolaeva, E. A. Grigorieva, A. V. Pronin |
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Jazyk: | ruština |
Rok vydání: | 2014 |
Předmět: | |
Zdroj: | Медицинская иммунология, Vol 14, Iss 4-5, Pp 399-402 (2014) |
Druh dokumentu: | article |
ISSN: | 1563-0625 2313-741X |
DOI: | 10.15789/1563-0625-2012-4-5-399-402 |
Popis: | Abstract. We have shown that polyprenyl phosphate (phosprenyl) competes with interleukin 2 for binding with serum γ-globulin. It was also demonstrated that phosprenyl restores delayed type hypersensitivity induced by Listeria monocytogenes, after its inhibition with a γ-globulin which binds to IL-2 and blocks its activity. A role of serum γ-globulin and Phosprenyl in regulation of IL-2-dependent processes is discussed. |
Databáze: | Directory of Open Access Journals |
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