| Autor: |
CHAI Jianxin, LI Ying, ZHOU Yuzhi, YOU Lirong, ZHANG Hui, WANG Gaoli, WANG Yin, ZHANG Yiyang |
| Jazyk: |
čínština |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Zhongguo shipin weisheng zazhi, Vol 34, Iss 5, Pp 924-930 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1004-8456 |
| DOI: |
10.13590/j.cjfh.2022.05.010 |
| Popis: |
ObjectiveTo obtain basic safety data， the systematic toxicology of Scutellaria baicalensis Georgi leaf was studied.MethodsThe extract of Scutellaria baicalensis Georgi leaf as test substance， the systematic toxicology safety of Scutellaria baicalensis Georgi leaf was evaluated by the national food safety standards of acute oral toxicity， bacterial reverse mutation assay， micronuclear test of mammalian， chromosome aberration test of spermatocyte in mice and 90 day oral toxicity test.ResultsThe LD50 of acute oral toxicity on Scutellaria baicalensis Georgi leaf extract was greater than 20.0 g/kg∙BW in male and female mice， simultaneously the LD50 was greater than 15.0 g/kg∙BW in male and female rats， which meant actual non-toxic. The detection results of bacterial reverse mutation assay， micronuclear test of mammalian and chromosom aberration test of spermatocyte in mice were negative. The 90 d oral toxicity test showed that compared with the control group， there were no significant differences in the body weight， food intake， food utilization rate， hematology and blood biochemistry in the test groups of 2.0， 4.0， 8.0 g/kg∙BW.ConclusionUnder the conditions of this experiment， toxic effects of Scutellaria baicalensis Georgi leaf extract on experimental animals were not found. After conversion， the NOAEL value of Scutellaria baicalensis Georgi leaf was 24.0 g/kg∙BW. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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