Molecular Characterization of Invasive Streptococcus dysgalactiae subsp. equisimilis, Japan

Autor: Takeaki Wajima, Miyuki Morozumi, Shigeo Hanada, Katsuhiko Sunaoshi, Naoko Chiba, Satoshi Iwata, Kimiko Ubukata
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Emerging Infectious Diseases, Vol 22, Iss 2, Pp 247-254 (2016)
Druh dokumentu: article
ISSN: 1080-6040
1080-6059
DOI: 10.3201/eid2202.141732
Popis: We collected β-hemolytic streptococci (1,611 isolates) from patients with invasive streptococcal infections in Japan during April 2010–March 2013. Streptococcus dysgalactiae subsp. equisimilis (SDSE) was most common (n = 693); 99% of patients with SDSE infections were elderly (mean age 75 years, SD ±15 years). We aimed to clarify molecular and epidemiologic characteristics of SDSE isolates and features of patient infections. Bacteremia with no identified focus of origin and cellulitis were the most prevalent manifestations; otherwise, clinical manifestations resembled those of S. pyogenes infections. Clinical manifestations also differed by patient’s age. SDSE isolates were classified into 34 emm types; stG6792 was most prevalent (27.1%), followed by stG485 and stG245. Mortality rates did not differ according to emm types. Multilocus sequence typing identified 46 sequence types and 12 novel types. Types possessing macrolide- and quinolone-resistance genes were 18.4% and 2.6%, respectively; none showed β-lactam resistance. Among aging populations, invasive SDSE infections are an increasing risk.
Databáze: Directory of Open Access Journals
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