Skin Autofluorescence, as Marker of Accumulation of Advanced Glycation Endproducts and of Cumulative Metabolic Stress, Is Not Increased in Patients with Systemic Sclerosis
| Autor: | M. E. Hettema, H. Bootsma, R. Graaff, R. de Vries, C. G. M. Kallenberg, A. J. Smit |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | International Journal of Rheumatology, Vol 2011 (2011) |
| Druh dokumentu: | article |
| ISSN: | 1687-9260 1687-9279 |
| DOI: | 10.1155/2011/417813 |
| Popis: | Objective. To investigate whether advanced glycation endproducts (AGEs) in the skin are increased in patients with systemic sclerosis (SSc) and are related to the presence of disease-related and traditional cardiovascular risk factors. Methods. Skin autofluorescence, as a measure for the accumulation of AGEs, was assessed by measuring UV-A light excitation-emission matrices (AF-EEMS) in 41 SSc patients and 41 age- and sex-matched controls. Traditional cardiovascular risk factors and disease-related risk factors were recorded. Results. Skin AF-EEMS did not differ between SSc patients and controls (1.68±0.58 a.u. versus 1.63±0.41 a.u., P=0.684). Skin AF-EEMS in SSc patients was associated with levels of CRP (r=0.44, P=0.004), Medsger's severity scale (r=0.45, P=0.006), and use of agents intervening in the renin-angiotensin system (r=0.33, P=0.027). When analysing SSc patients and controls together, in multivariate analysis, only age and use of agents intervening in the renin-angiotensin system were independently associated with AF-EEMS. Conclusion. These data demonstrate that skin AGEs are not increased in SSc patients. |
| Databáze: | Directory of Open Access Journals |
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