Improvement of glucose metabolism disorder by wheat dietary fibre depended on the intake mode and regulated through TLRs/NF-κB/TNF pathway in db/db mice
| Autor: | Xinguo Liu, Shaojie Pang, Aoxiang Li, Yong Wang, Wei Fang, Wentao Qi |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Food and Agricultural Immunology, Vol 35, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 09540105 1465-3443 0954-0105 |
| DOI: | 10.1080/09540105.2024.2420110 |
| Popis: | To study the effect of wheat dietary fibre (WDF) on glucose metabolism disorder and its mechanisms, 6-week-old db/db mice were given WDF by adding to diet or oral-gavage. The results showed that WDF by oral-gavage instead of adding to the feed can significantly reduce blood glucose levels. The levels of insulin and HOMA-IR were both decreased in the serum of WDF-gavaged mice as well as several inflammatory cytokines including TNF-α, IL-6 and IL-1β. WDF intake by gavage could better regulate the intestinal flora, thus inhibiting diabetes. The relative expressions of genes and proteins including TLR, P65, P50 and TNF-α were all significantly decreased by oral-gavaged WDF. Moreover, the ratio of phosphorylated p65 to total p65 was significantly decreased. In conclusion, ingestion of WDF by gavage can effectively improve glucose metabolism disorder in db/db mice by improving intestinal microbiota and regulating the TLRs/NF-κB/TNF pathway. |
| Databáze: | Directory of Open Access Journals |
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