Coagulation Factors and Natural Anticoagulants as Surrogate Markers of Preeclampsia and Its Subtypes: A Case–Control Study in a Ghanaian Population
| Autor: | Selina Mintaah BSc, MPhil, Enoch Odame Anto BSc, MPhil, PhD, Wina Ivy Ofori Boadu BSc, MPhil, PhD, Benedict Sackey BSc, MPhil, PhD, Lilian Antwi Boateng BSc, MSc, PhD, Ezekiel Ansah BSc, Emmanuel Ekow Korsah BSc, Joseph Frimpong BSc, Valentine Christian Kodzo Tsatsu Tamakloe BSc, Peter Kuugemah Selleh BSc, MPhil, David Amoah Afrifa BSc, MPhil, Abdul-Razak Saasi BSc, MPhil, Ebenezer Senu BSc, Lawrence Agyemang Duah BSc, MPhil, Stephen Opoku BSc, John Paul Amoah BSc, MPhil, Patrick Adu BSc, PhD, Joseph Boachie BSc, MSc, PhD, Dorcas Asamoah Nyamekye BSc, MPhil, David Sebbie Sackey BSc, MPhil, MLSD, Yaw Amo Wiafe BSc, MSc, PhD, Otchere Addai-Mensah MD, MSc, PhD |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Clinical and Applied Thrombosis/Hemostasis, Vol 29 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1938-2723 10760296 |
| DOI: | 10.1177/10760296231204604 |
| Popis: | Preeclampsia (PE) is associated with endothelial injury and hemostatic abnormalities. However, the diagnostic role of coagulation parameters and natural anticoagulants in predicting PE has not been explored in Ghana. This study assessed plasma levels of these factors as surrogate markers of PE and its subtypes. This case–control study included 90 women with PE (cases) and 90 normotensive pregnant women (controls). Blood samples were drawn for the estimation of complete blood count and coagulation tests. The prothrombin time (PT), activated partial thromboplastin time (APTT), and the calculation of the international normalized ratio (INR) were determined by an ACL elite coagulometer while the levels of protein C (PC), protein S (PS), antithrombin III (ATIII), and D-dimers were also measured using the solid-phase sandwich enzyme-linked immunosorbent assay (ELISA) method. All statistical analyses were performed using the R Language for Statistical Computing. Results showed significantly ( p |
| Databáze: | Directory of Open Access Journals |
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