The Effect of Black Cohosh on Ki67 expression and Tumor Volume: A Pilot Study of Ductal Carcinoma in Situ Patients

Autor: Amelia A. Trant MD, Anees Chagpar MD, MBA, MPH, FACS, FRCS(C), Wei Wei PhD, Veronique Neumeister MD, David Rimm MD, PhD, Karen Stavris RN, Bonnie Lurie RN, Courtney Frederick RN, Liva Andrejeva MD, Madhavi Raghu MD, Brigid Killelea MD, MPH, FACS, Nina Horowitz MD, FACS, Donald Lannin MD, Elspeth Knill-Selby APRN, Tracy Sturrock APRN, Erin Hofstatter MD
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Integrative Cancer Therapies, Vol 21 (2022)
Druh dokumentu: article
ISSN: 1552-695X
15347354
DOI: 10.1177/15347354221137290
Popis: Background: Black cohosh (BC) ( Cimicifuga racemosa ) may prevent and treat breast cancer through anti-proliferative, pro-apoptotic, anti-estrogenic, and anti-inflammatory effects. This study sought to evaluate the effect of BC on tumor cellular proliferation, measured by Ki67 expression, in a pre-operative window trial of ductal carcinoma in situ (DCIS) patients. Methods: Patients were treated pre-operatively for 2 to 6 weeks with BC extract. Eligible subjects were those who had DCIS on core biopsy. Ki67 was measured using automated quantitative immunofluorescence (AQUA) pre/post-operatively. Ki67, tumor volume, and hormone changes were assessed with 2-sided Wilcoxon signed-rank tests, α = .05. Results: Thirty-one patients were treated for an average of 24.5 days (median 25; range 15-36). Ki67 decreased non-significantly (n = 26; P = .20; median pre-treatment 1280, post-treatment 859; range pre-treatment 175-7438, post-treatment 162-3370). Tumor volume, estradiol, and FSH did not change significantly. No grade 3 or 4 adverse events were reported. Conclusions: BC use showed no significant impact on cellular proliferation, tumor volume, or invasive disease upgrade rates in DCIS patients. It was well-tolerated, with no observed significant toxicities. Further study is needed to elucidate BC’s role in breast cancer treatment and prevention. ClinicalTrials.gov Identifier: NCT01628536 https://clinicaltrials.gov/ct2/show/NCT01628536
Databáze: Directory of Open Access Journals
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