| Autor: |
Konstantinidis Georgios, Kaćanski Nataša, Kolarović Jovanka, Konstantinidis Nada, Vijatov-Đurić Gordana |
| Jazyk: |
English<br />Serbian |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Srpski Arhiv za Celokupno Lekarstvo, Vol 139, Iss 11-12, Pp 749-752 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
0370-8179 |
| DOI: |
10.2298/SARH1112749K |
| Popis: |
Introduction. L-asparaginase (L-ASP) is one of the most effective medications for the treatment of acute lymphoblastic leukaemia (ALL) in children, and allergic reactions to the therapy are considered the most significant side effects. Objective. The aim of this study was to determine the prevalence and type of allergic reactions, as well as to identify potential risk factors for the development of allergic reactions during L-ASP therapy in children with ALL. Methods. The study encompassed 70 patients under 18 years of age, who were treated at the Institute for Child and Youth Healthcare of Vojvodina, Novi Sad in the period January 2000 - June 2009. We analyzed the frequency and type of allergic reactions during the administration of L-ASP, the onset of allergic reaction in relation to the phase of therapy of underlying disease, as well as the prevalence of allergic reactions in relation to drug administration method. Results. Allergic reaction manifested in 17 patients (24%). In 14 patients (82%) allergic reaction to L-ASP manifested as urticaria, bronchospasm or anaphylaxis, whereas a mild local reaction was observed in only three patients (18%). In a group treated, according to the high-risk protocol, the prevalence of allergic reactions was statistically significantly higher in the intermediate-risk group of patients (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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