Recent Advances in the Chemical Biology of N-Glycans

Autor:	Asuka Shirakawa, Yoshiyuki Manabe, Koichi Fukase
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	N-glycan chemical biology glycan array NMR glycoprotein lectin Organic chemistry QD241-441
Zdroj:	Molecules, Vol 26, Iss 4, p 1040 (2021)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules26041040
Popis:	Asparagine-linked N-glycans on proteins have diverse structures, and their functions vary according to their structures. In recent years, it has become possible to obtain high quantities of N-glycans via isolation and chemical/enzymatic/chemoenzymatic synthesis. This has allowed for progress in the elucidation of N-glycan functions at the molecular level. Interaction analyses with lectins by glycan arrays or nuclear magnetic resonance (NMR) using various N-glycans have revealed the molecular basis for the recognition of complex structures of N-glycans. Preparation of proteins modified with homogeneous N-glycans revealed the influence of N-glycan modifications on protein functions. Furthermore, N-glycans have potential applications in drug development. This review discusses recent advances in the chemical biology of N-glycans.
Databáze:	Directory of Open Access Journals
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